Benjamin Mendy (cedera lutut; perkiraan kembali pada 18/4/2018), Gabriel Jesus (ligamen lutut; ??), Vincent Kompany (betis; 2/1/2018), Fabian Delph (otot; 2/1/2018), Phil Foden (engkel; ??), Kevin De Bruyne (lutut; ??)
Eric Bailly (engkel; 3/3/2018), Zlatan Ibrahimovic (lutut; 31/1/2018), Romelu Lukaku (kepala; 15/1/2018), Marouane Fellaini (lutut; 15/1/2018), Antonio Valencia (paha; ??), Michael Carrick (kondisi jantung; ??)
Charly Musonda (pangkal paha; 6/1/2018), David Luiz (lutut; 6/1/2018)
Nathaniel Clyne (punggung; 10/2/2018), Jordan Henderson (paha; 22/1/2018), Alberto Moreno (engkel; 14/1/2018), Mohamed Salah (pangkal paha; 14/1/2018), Philippe Coutinho (paha; 14/1/2018), Marko Grujic (tulang jari; ??), Daniel Sturridge (otot; ??), Adam Bogdan (ligamen ACL; ??)
Olivier Giroud (paha; 14/1/2018), Aaron Ramsey (paha; 7/1/2018), Nacho Monreal (engkel; 7/1/2018), Mesut Oezil (lutut; 3/1/2018), Sead Kolasinac (lutut; ??), Santi Cazorla (betis; ??)
Harry Kane (demam; 2/1/2018), Mousa Dembele (pinggang; 2/1/2018), Toby Alderweireld (hamstring; 10/2/2018), Victor Wanyama (kartilago lutut; 2/1/2018)