I Rossoblu kembali mengandalkan winger tajam Riccardo Orsolini untuk melumpuhkan tuan rumah.
Lazio (3-5-2)
1-Thomas Strakosha; 4-Patric,3-Luiz Felipe, 26-Stefan Radu; 29-Manuel Lazzari, 21-Sergej Milinkovic-Savic, 6-Lucas Leiva, 10-Luis Alberto, 22-Jony; 11-Joaquin Correa, 17-Ciro Immobile
Subs: Jordan Lukaku, Djavan Anderson, Bastos, Marco Parolo, Felipe Caicedo, Guido Guerrieri, Silvio Proto, Andre Anderson, Danilo Cataldi, Bobby Adekanye, Jorge Silva, Denis Vavro
Pelatih: Simone Inzaghi
Bologna (4-5-1)
28-Lukasz Skorupski; 14-Takehiro Tomiyasu, 23-Danilo, 13-Mattia Bani, 4-Stefano Denswil; 7-Orsolini, 16-Andrea Poli, 30-Jerdy Schouten, 21-Roberto Soriano, 99-MusaBarrow; 24-Rodrigo Palacio
Subs: Angelo da Costa, Gary Medel, Federico Bonini, Nicolas Dominguez, Federico Santander, Nicola Sansone, Andreas Skov Olsen, Gabriele Corbo, Musa Juwara, Andri Fannar Baldursson, Mouhamadou Sarr
Pelatih: Sinisa Mihajlovic