Berikut hasil dan klasemen pekan ke-13 Liga Inggris 2021-2022 pada Sabtu (27/11/2021) hingga Minggu (28/11/2021).
- Arsenal 2-0 Newcastle United (Bukayo Saka 56', Gabriel Martinelli 66')
- Crystal Palace 1-2 Aston Villa (Marc Guehi 90+5'; Matt Tarfett 15', John McGinn 86')
- Norwich City 0-0 Wolverhampton
- Liverpool 4-0 Southampton (Diogo Jota 2', 32', Thiago 37', Virgil van Dijk 52')
- Brighton and Hove Albion 0-0 Leeds United
- Brentford 1-0 Everton (Ivan Toney 24'-pen)
- Leicester City 4-2 Watford (James Maddison 16', Jamie Vardy 34', 42', Ademola Lookman 68'; Joshua King 30'-pen, Emmanuel Dennis 61')
- Manchester City 2-1 West Ham United (Ilkay Guendogan 33, Fernandinho 90'; Manuel Lanzini 90+4')
- Chelsea 1-1 Manchester United (Jorginho 69'-pen; Jadon Sancho 50')